C-C chemokine receptor type 1 mediates osteopontin-promoted metastasis in hepatocellular carcinoma

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C‐C chemokine receptor type 1 mediates osteopontin‐promoted metastasis in hepatocellular carcinoma

In the hepatocellular carcinoma (HCC) microenvironment, chemokine receptors play a critical role in tumorigenesis and metastasis. Our previous studies have found that osteopontin (OPN) is a promoter for HCC metastasis. However, the role of chemokine receptors in OPN-induced HCC metastasis remains unclear. In this study, we demonstrate that OPN is dramatically elevated in HCC tissues with metast...

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ژورنال

عنوان ژورنال: Cancer Science

سال: 2018

ISSN: 1347-9032

DOI: 10.1111/cas.13487